Analytical Data
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Gene name
GNG11
- Application
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Alternative Names
GNG11;GNGT11;Guanine nucleotide-binding Protein G(I)/G(S)/G(O) subunit gamma-11
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61952
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Expression Region
1-70aa
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AA Sequence
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED KNPFKEKGSC
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GNG11, also known as G protein subunit gamma 11, is an essential component of heterotrimeric G proteins, playing a pivotal role in various signaling pathways that mediate a range of physiological processes. Research into GNG11 has gained momentum due to its involvement in the regulation of cellular functions such as growth, differentiation, and apoptosis. Aberrations in GNG11 signaling have been implicated in several diseases, including cancer and cardiovascular disorders, highlighting its potential as a therapeutic target. The generation of recombinant GNG11 protein facilitates detailed studies of its biochemical properties, interaction with G protein-coupled receptors (GPCRs), and overall role in signal transduction. Understanding the structure-function relationship of GNG11 through recombinant technology can offer insights into its mechanism of action and pave the way for the development of drugs that modulate G protein-mediated pathways. This research is crucial, as it not only enhances our comprehension of GNG11's role in normal physiology but also its pathological contributions, thereby addressing significant gaps in current biomedical knowledge.
