Analytical Data
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基因名
GNG11
- Application
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别名
GNG11;GNGT11;Guanine nucleotide-binding Protein G(I)/G(S)/G(O) subunit gamma-11
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61952
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表达区间
1-70aa
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氨基酸序列
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED KNPFKEKGSC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNG11, also known as G protein subunit gamma 11, is an essential component of heterotrimeric G proteins, playing a pivotal role in various signaling pathways that mediate a range of physiological processes. Research into GNG11 has gained momentum due to its involvement in the regulation of cellular functions such as growth, differentiation, and apoptosis. Aberrations in GNG11 signaling have been implicated in several diseases, including cancer and cardiovascular disorders, highlighting its potential as a therapeutic target. The generation of recombinant GNG11 protein facilitates detailed studies of its biochemical properties, interaction with G protein-coupled receptors (GPCRs), and overall role in signal transduction. Understanding the structure-function relationship of GNG11 through recombinant technology can offer insights into its mechanism of action and pave the way for the development of drugs that modulate G protein-mediated pathways. This research is crucial, as it not only enhances our comprehension of GNG11's role in normal physiology but also its pathological contributions, thereby addressing significant gaps in current biomedical knowledge.
