Analytical Data
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Gene name
CAMK2g
- Application
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Alternative Names
CAMK2g；CAMK；CAMK-II；CAMKG；Calcium/calmodulin-dependent Protein kinase type II subunit gamma
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13555
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Expression Region
1-527aa
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AA Sequence
MATTATCTRFTDDYQLFEELGKGAFSGVRRCVKKTPTQEYAAKIINTKKL SARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFE DIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKG AAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN QMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGV KKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEII KITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFEN LLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEE TRVWHRRDGKWLNVHYHCSGAPAAPLQ
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Molecular Weight
84 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Calcium/calmodulin-dependent protein kinase II gamma (CAMK2g) is a member of the CAMK2 family, which plays significant roles in various cellular processes, particularly in the nervous system. It is known for its involvement in synaptic plasticity, learning, and memory, functioning as a critical mediator of calcium signaling pathways. Research has highlighted CAMK2g's unique regulatory mechanisms, distinguishing it from other isoforms of CAMK2, such as CAMK2a and CAMK2b, primarily through its specific expression patterns and functional properties. Dysregulation of CAMK2g has been implicated in several neurodegenerative diseases and psychiatric disorders, making it a target for understanding the molecular underpinnings of these conditions. Given its pivotal roles, the recombinant expression and characterization of CAMK2g are essential for elucidating its biochemical properties, interactions with substrate proteins, and its regulation by calcium and calmodulin. Recombinant proteins also facilitate the development of potential therapeutic strategies aimed at modulating CAMK2g activity in disease contexts, advancing our knowledge of synaptic function and plasticity. Therefore, studies focused on CAMK2g not only enhance our comprehension of its physiological roles but also open avenues for novel interventions in neuroscience and therapeutic applications.
