Analytical Data
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基因名
CAMK2g
- Application
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别名
CAMK2g；CAMK；CAMK-II；CAMKG；Calcium/calmodulin-dependent Protein kinase type II subunit gamma
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13555
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表达区间
1-527aa
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氨基酸序列
MATTATCTRFTDDYQLFEELGKGAFSGVRRCVKKTPTQEYAAKIINTKKL SARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFE DIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKG AAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWAC GVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN QMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGV KKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEII KITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFEN LLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEE TRVWHRRDGKWLNVHYHCSGAPAAPLQ
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分子量
84 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Calcium/calmodulin-dependent protein kinase II gamma (CAMK2g) is a member of the CAMK2 family, which plays significant roles in various cellular processes, particularly in the nervous system. It is known for its involvement in synaptic plasticity, learning, and memory, functioning as a critical mediator of calcium signaling pathways. Research has highlighted CAMK2g's unique regulatory mechanisms, distinguishing it from other isoforms of CAMK2, such as CAMK2a and CAMK2b, primarily through its specific expression patterns and functional properties. Dysregulation of CAMK2g has been implicated in several neurodegenerative diseases and psychiatric disorders, making it a target for understanding the molecular underpinnings of these conditions. Given its pivotal roles, the recombinant expression and characterization of CAMK2g are essential for elucidating its biochemical properties, interactions with substrate proteins, and its regulation by calcium and calmodulin. Recombinant proteins also facilitate the development of potential therapeutic strategies aimed at modulating CAMK2g activity in disease contexts, advancing our knowledge of synaptic function and plasticity. Therefore, studies focused on CAMK2g not only enhance our comprehension of its physiological roles but also open avenues for novel interventions in neuroscience and therapeutic applications.
