Analytical Data
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基因名
GNB3
- Application
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别名
GNB3;Guanine nucleotide-binding Protein G(I)/G(S)/G(T) subunit beta-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16520
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表达区间
1-340aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMGEMEQL RQEAEQLKKQ IADARKACAD VTLAELVSGL EVVGRVQMRT RRTLRGHLAK IYAMHWATDS KLLVSASQDG KLIVWDSYTT NKVHAIPLRS SWVMTCAYAP SGNFVACGGL DNMCSIYNLK SREGNVKVSR ELSAHTGYLS CCRFLDDNNI VTSSGDTTCA LWDIETGQQK TVFVGHTGDC MSLAVSPDFN LFISGACDAS AKLWDVREGT CRQTFTGHES DINAICFFPN GEAICTGSDD ASCRLFDLRA DQELICFSHE SIICGITSVA FSLSGRLLFA GYDDFNCNVW DSMKSERVGI LSGHDNRVSC LGVTADGMAV ATGSWDSFLK IWN
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNB3, a subunit of the guanine nucleotide-binding protein (G-protein), plays a critical role in cellular signaling pathways, influencing various physiological processes such as neurotransmission, hormone response, and sensory perception. Studies have shown associations between GNB3 polymorphisms and several conditions, including hypertension, obesity, and mood disorders, indicating its potential as a therapeutic target. Recombination techniques have been employed to produce GNB3 recombinant proteins, facilitating the investigation of its structural and functional properties. Understanding the signaling mechanisms mediated by GNB3 is essential for elucidating its role in disease and developing targeted therapies. The production of recombinant GNB3 proteins allows researchers to perform binding assays, activity assays, and interaction studies, ultimately contributing to a better understanding of its biological significance and potential implications in pharmacology. The advancements in recombinant DNA technology have made it more feasible to generate and purify these proteins, paving the way for more precise studies on their role in health and disease.
