Analytical Data
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基因名
GGPS1
- Application
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别名
GGPS1;Geranylgeranyl pyrophosphate synthase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95749
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表达区间
1-300aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMEKTQETVQRILLEPYKYLLQLPGKQVRTK LSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAH SIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDI YWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV QNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGG NPELVALVKHLSKMFKEENE
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GGPS1 (Geranylgeranyl pyrophosphate synthase 1) gene encodes an enzyme crucial for the biosynthesis of geranylgeranyl pyrophosphate, a key intermediate in the synthesis of isoprenoids, which are vital for various biological processes, including cell signaling, growth, and membrane integrity. Abnormalities in GGPS1 expression have been linked to several pathological conditions, including cancer and cardiovascular diseases. Researchers have been focused on characterizing the structure and function of the GGPS1 recombinant protein, which allows for a better understanding of its enzymatic mechanisms and potential regulatory roles in metabolic pathways. This protein serves as a valuable tool for studying the effects of geranylgeranylation on protein function and signaling pathways. Furthermore, by utilizing recombinant DNA technology to produce GGPS1, scientists can explore its enzymatic activity, substrate specificity, and interaction with other proteins, thereby shedding light on its involvement in disease processes. The continued investigation of GGPS1 and its recombinant protein is crucial for developing therapeutic strategies aimed at modulating its activity in various diseases, making it a significant target in the field of molecular biology and pharmacology. This research will not only enhance our understanding of isoprenoid metabolism but also aid in the identification of potential biomarkers and novel drug targets for therapeutic intervention.
