Analytical Data
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基因名
HEYL
- Application
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别名
bHLHb33; Class B basic helix loop helix protein 33; Class B basic helix-loop-helix protein 33; Hairy enhancer of split related with YRPW motif like; Hairy related transcription factor 3; Hairy-related transcription factor 3; Hairy/enhancer of split related with YRPW motif 3; Hairy/enhancer of split related with YRPW motif like; Hairy/enhancer of split related with YRPW motif like protein; Hairy/enhancer-of-split related with YRPW motif-like protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQ87
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表达区间
1-328aa
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氨基酸序列
MKRPKEPSGS DGESDGPIDV GQEGQLSQMA RPLSTPSSSQ MQARKKHRGI IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA TGGTGFFDAR ALAVDFRSIG FRECLTEVIR YLGVLEGPSS RADPVRIRLL SHLNSYAAEM EPSPTPTGPL AFPAWPWSFF HSCPGLPALS NQLAILGRVP SPVLPGVSSP AYPIPALRTA PLRRATGIIL PARRNVLPSR GASSTRRARP LERPATPVPV APSSRAARSS HIAPLLQSSS PTPPGPTGSA AYVAVPTPNS SSPGPAGRPA GAMLYHSWVS EITEIGAF
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HEYL (Hes-related protein with YRPW motif) is a member of the basic helix-loop-helix (bHLH) transcription factor family, known for its role in regulating cell differentiation, proliferation, and development. Initially identified in studies related to the Notch signaling pathway, HEYL has emerged as a key player in multiple biological processes, including neuronal development and cardiac function. Research has shown that HEYL can interact with other transcription factors and signaling pathways, highlighting its importance in embryonic development and tissue homeostasis. Its expression is tightly regulated, and dysregulation of HEYL has been implicated in various diseases, including cancer and cardiovascular disorders. Recent studies focusing on HEYL recombinant proteins aim to elucidate its functional mechanisms at the molecular level, leveraging biotechnological advancements to produce and analyze these proteins. By harnessing the power of recombinant DNA technology, researchers are investigating HEYL's role in gene regulation and its impact on cellular signaling networks. The study of HEYL recombinant proteins not only provides insights into fundamental biological processes but also opens potential avenues for therapeutic interventions targeting HEYL-related pathways in disease contexts. Such research could lead to the development of novel strategies for managing diseases associated with HEYL dysregulation, emphasizing the importance of understanding this transcription factor in health and disease.
