Analytical Data
-
Gene name
HES6
- Application
-
Alternative Names
HES6; BHLHB41; Transcription cofactor HES-6; C-HAIRY1; Class B basic helix-loop-helix protein 41; bHLHb41; Hairy and enhancer of split 6
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q96HZ4
-
Expression Region
1-224aa
-
AA Sequence
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
-
Molecular Weight
50.5 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HES6, or Hairy Enhancer of Split 6, is a member of the Hes family of basic helix-loop-helix (bHLH) transcription factors, which play critical roles in developmental processes and cellular differentiation. These proteins are known to be involved in the Notch signaling pathway, a key regulatory mechanism in various biological contexts, including neurogenesis, cell fate determination, and tumorigenesis. The study of HES6 and its recombinant protein has gained attention due to its potential implications in understanding developmental disorders and its role in cancer biology. Recent research suggests that HES6 may influence the expression of target genes fundamental to maintaining stemness in cancer stem cells and may also have implications in the development of resistance to therapies. The recombinant expression of HES6 facilitates investigations into its protein structure, function, and interactions within cellular contexts, providing insights into its mechanisms of action. Understanding HES6's role at the molecular level can contribute to therapeutic strategies targeting Notch signaling-related diseases, underscoring the importance of recombinant proteins in elucidating the complexities of gene regulation and protein interactions in developmental and pathological processes.
