Analytical Data
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基因名
HES6
- Application
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别名
HES6; BHLHB41; Transcription cofactor HES-6; C-HAIRY1; Class B basic helix-loop-helix protein 41; bHLHb41; Hairy and enhancer of split 6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96HZ4
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表达区间
1-224aa
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氨基酸序列
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
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分子量
50.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HES6, or Hairy Enhancer of Split 6, is a member of the Hes family of basic helix-loop-helix (bHLH) transcription factors, which play critical roles in developmental processes and cellular differentiation. These proteins are known to be involved in the Notch signaling pathway, a key regulatory mechanism in various biological contexts, including neurogenesis, cell fate determination, and tumorigenesis. The study of HES6 and its recombinant protein has gained attention due to its potential implications in understanding developmental disorders and its role in cancer biology. Recent research suggests that HES6 may influence the expression of target genes fundamental to maintaining stemness in cancer stem cells and may also have implications in the development of resistance to therapies. The recombinant expression of HES6 facilitates investigations into its protein structure, function, and interactions within cellular contexts, providing insights into its mechanisms of action. Understanding HES6's role at the molecular level can contribute to therapeutic strategies targeting Notch signaling-related diseases, underscoring the importance of recombinant proteins in elucidating the complexities of gene regulation and protein interactions in developmental and pathological processes.
