Analytical Data
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基因名
Tlr11
- Application
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别名
Tlr11；Gm287；Tlr12；Toll-like receptor 11
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6R5P0
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表达区间
769-926aa
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氨基酸序列
RGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLLFLEPLDRQRLHSYHRLSRWLQKEDYFDLSQGKVEWNSFCEQLKRRLSKAGQERD
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分子量
25.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Toll-like receptor 11 (TLR11) is a member of the Toll-like receptor family, which plays a crucial role in the innate immune system by recognizing pathogen-associated molecular patterns. Research has shown that TLR11 is primarily expressed in the urinary tract and has a significant role in the detection of uropathogenic Escherichia coli. It is also involved in the immune response to certain protozoan infections, such as those caused by Toxoplasma gondii and other pathogens. Despite its importance, the biological mechanisms underlying TLR11 signaling and its potential implications in disease management have not been fully elucidated. Developing recombinant TLR11 proteins has become a focal point in research, enabling scientists to investigate its signaling pathways, ligand interactions, and functional relevance in immune responses. The expression and purification of TLR11 in a recombinant form provide tools for detailed immunological studies and the potential for therapeutic applications, such as vaccine development and enhancement of anti-infective strategies. Understanding TLR11’s role may pave the way for innovative approaches to manipulate the immune response in various infectious and inflammatory diseases, highlighting the necessity for ongoing research in this area.
