Analytical Data
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基因名
HTRA1
- Application
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别名
HTRA1；HTRA；PRSS11；Serine protease HTRA1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92743
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表达区间
23-480aa
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氨基酸序列
QLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPE GAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSD ANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFI ADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVV TNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSE LRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAI INYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA KGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTP AEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMIT VIPEEIDP
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTRA1 (High-temperature requirement A serine peptidase 1) is a serine protease that has garnered significant attention in biomedical research due to its involvement in various pathological processes, particularly in age-related diseases such as age-related macular degeneration (AMD). This extracellular enzyme is known to play a crucial role in the regulation of cellular processes, including protein quality control, apoptosis, and extracellular matrix remodeling. Abnormal HTRA1 expression has been linked to increased susceptibility to AMD, making it a potential biomarker and therapeutic target for this vision-threatening condition. Additionally, HTRA1 is involved in neurodegenerative diseases and certain cancers, further underscoring its importance in human health. The recombinant form of HTRA1 is particularly useful for detailed biochemical and structural studies, allowing researchers to dissect its functional mechanisms, enzyme activity, and interaction with substrates and inhibitors. The production of HTRA1 recombinant protein enables high-throughput screening and the development of novel therapeutic strategies, including small molecules or monoclonal antibodies that target the dysregulated pathways associated with its aberrant expression. Overall, HTRA1 recombinant protein research highlights its significance not only in understanding fundamental biological processes but also in identifying innovative approaches to disease treatment and prevention.
