Analytical Data
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Gene name
HADHSC
- Application
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Alternative Names
3 hydroxyacyl Coenzyme A dehydrogenase; HAD; HADH; HADH1; HADHSC; HADHSC. formerly; HADSC. formerly; HCDH; HCDH_HUMAN; HHF4; Hydroxyacyl CoA dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase. mitochondrial; L 3 hydroxyacyl Coenzyme A dehydrogenase short chain; M SCHAD; Medium and short chain L 3 hydroxyacyl coenzyme A dehydrogenase
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16836
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Expression Region
1-314aa
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AA Sequence
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
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Molecular Weight
60.28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The HADHSC (Hydroxyacyl-CoA Dehydrogenase Short-Chain) is an enzyme that plays a critical role in the fatty acid oxidation pathway, influencing lipid metabolism and energy production. Research on HADHSC is driven by its significance in metabolic disorders, including obesity, diabetes, and cardiovascular diseases. Understanding the structure-function relationship of HADHSC can provide insights into its catalytic mechanisms and potential regulatory pathways. Recent studies have highlighted the importance of HADHSC in maintaining cellular energy homeostasis and its involvement in various physiological and pathological processes. The recombinant production of HADHSC allows for detailed characterization and examination of its enzymatic properties, paving the way for potential therapeutic applications. Investigating this enzyme can also lead to advancements in metabolic engineering and synthetic biology, whereby insights gained may facilitate the development of novel strategies for disease intervention and management. Overall, research on HADHSC not only enhances our understanding of lipid metabolism but also contributes to the identification of new targets for pharmacological intervention in metabolic diseases.
