Analytical Data
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Gene name
HABP4
- Application
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Alternative Names
HABP4; Intracellular hyaluronan-binding protein 4; IHABP-4; IHABP4; Hyaluronan-binding protein 4; Ki-1/57 intracellular antigen
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5JVS0
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Expression Region
1-308aa
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AA Sequence
MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDEAAAAAGAGPRGGRSPAGASGHRAGAGGRRESQKERKSLPAPVAQRPDSPGGGLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEKVPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPSKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAEVVMQDVAPNPDDPEDFPALS
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Molecular Weight
60.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HABP4, or Hyaluronan-Binding Protein 4, is a member of the hyaluronic acid-binding protein family that plays a significant role in various biological processes, including cell adhesion, migration, and proliferation. The interest in HABP4 arises from its potential involvement in pathological conditions such as cancer, where hyaluronan interactions can influence tumor progression and metastasis. The study of HABP4 recombinant protein has gained traction due to its ability to bind to hyaluronan, suggesting a functional role in extracellular matrix interactions and tissue remodeling. Research has focused on characterizing the structure and function of HABP4, exploring its binding affinities and the molecular mechanisms by which it mediates cellular processes. Understanding the role of HABP4 in disease mechanisms can provide insights into novel therapeutic approaches targeting hyaluronan pathways, making it a valuable subject for both basic and applied research in biomedicine. As recombinant technologies continue to advance, producing HABP4 in heterologous systems allows for detailed functional studies and potential applications in drug development, ultimately contributing to a deeper understanding of its biological significance and therapeutic potential.
