Analytical Data
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Gene name
GTDC1
- Application
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Alternative Names
GTDC1; Glycosyltransferase-like domain-containing protein 1; Mannosyltransferase-like protein Xa; Mat-Xa
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q4AE62
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Expression Region
1-373aa
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AA Sequence
MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRARTSALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKCQVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNFNSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGGVDNQQRLLHIVWPHRWLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL
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Molecular Weight
69.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GTDC1 (Glycosyltransferase Domain Containing 1) is a significant protein involved in glycosylation processes, which play a critical role in various biological functions, including cell signaling, immune response, and protein stability. The study of GTDC1 has gained attention due to its potential implications in the development of certain diseases, including cancer and metabolic disorders. Researchers have identified that GTDC1 is involved in the biosynthesis of complex carbohydrates, which are crucial for cellular interactions and communication. Understanding the structure and function of GTDC1 can provide insights into its enzymatic activity and its role in glycan architecture. Furthermore, as glycosylation patterns are often altered in disease states, GTDC1 could serve as a biomarker for diagnosing or evaluating disease progression. Recombination techniques to produce GTDC1 in vitro allow for more detailed functional studies, enabling scientists to investigate its interaction with different substrates and other glycosyltransferases. The insights gained from such studies may lead to novel therapeutic approaches that target glycosylation pathways, making GTDC1 a promising candidate for further investigation in both basic research and clinical applications.
