Analytical Data
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Gene name
MT1M
- Application
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Alternative Names
MT1M；MT1K；Metallothionein-1M
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N339
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Expression Region
1-61aa
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AA Sequence
MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC A
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Molecular Weight
6.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MT1M, or metallothionein 1M, is a low-molecular-weight protein characterized by its high cysteine content, which allows it to bind heavy metals and reactive oxygen species. This protein is part of a larger family of metallothioneins known for their role in metal homeostasis, detoxification, and protection against oxidative stress. Research indicates that MT1M is involved in various biological processes, including cellular signaling, apoptosis, and the response to environmental stress. Its expression is often upregulated in response to heavy metal exposure, highlighting its potential role in metal detoxification mechanisms. Furthermore, studies have shown that MT1M may be associated with certain pathological conditions, including cancer and neurodegenerative diseases, further emphasizing its significance in health and disease. The understanding of MT1M's structure, function, and regulation is critical for elucidating its role in these processes and could lead to potential therapeutic applications, including the development of strategies to manipulate its expression or activity in disease contexts. As research continues to unravel the complexities of MT1M, it offers promising insights into the broader implications of metallothioneins in physiological and pathological states.
