Analytical Data
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基因名
FCGR2B
- Application
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别名
FCGR2B；CD32；FCG2;Low affinity immunoglobulin gamma Fc region receptor II-b
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31994
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表达区间
46-217aa
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氨基酸序列
APPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHT QPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYH CTGNIGYTLYSSKPVTITVQAP
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FCGR2B (Fc gamma receptor IIb) is a key inhibitory receptor primarily expressed on the surface of B cells, monocytes, and other immune cells. It plays a critical role in modulating immune responses by regulating antibody production, phagocytosis, and the activation of immune cells. Dysregulation of FCGR2B has been implicated in various autoimmune diseases, infections, and cancers, making it a significant target for therapeutic intervention. Research into recombinant FCGR2B proteins has gained momentum due to their potential in understanding the mechanisms of immune regulation and their applications in immunotherapy. By studying these recombinant proteins, scientists aim to elucidate the receptor's structure-function relationship, examine its role in ligand binding, and assess its impact on cellular signaling pathways. Additionally, FCGR2B's involvement in antibody-dependent cellular cytotoxicity (ADCC) offers insights into enhancing the efficacy of therapeutic antibodies. Overall, the investigation of FCGR2B recombinant proteins not only advances our understanding of immune system dynamics but also opens new avenues for the development of targeted therapies in treating immune-related disorders.
