Analytical Data
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Gene name
KRT6C
- Application
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Alternative Names
KRT6C；KRT6E；Keratin. type II cytoskeletal 6C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48668
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Expression Region
2-564aa
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AA Sequence
ASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR NMQDLVEDLK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCASLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNVSVVQ STISSGYGGA SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS SVGGGSSTIK YTTTSSSSRK SYKH
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Molecular Weight
60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT6C, a member of the keratin family, plays a crucial role in the structural integrity and functionality of epithelial tissues. It is primarily expressed in stratified epithelia, such as skin, hair follicles, and the oral cavity, where it contributes to the formation of the cytoskeleton and the mechanical resilience of cells against stress and injury. Research has shown that abnormal expression of KRT6C is associated with various skin disorders, inflammatory conditions, and cancers, making it a significant focus of biomedical research. The study of recombinant KRT6C protein is particularly important for understanding its biochemical properties and interactions within cellular environments. By producing KRT6C recombinantly, researchers can analyze its structure-function relationship, investigate its role in cellular mechanisms such as proliferation and apoptosis, and explore its potential as a biomarker for disease diagnosis and progression. Additionally, recombinant KRT6C can be utilized in therapeutic applications, such as tissue engineering, where it may help in developing strategies for wound healing and skin regeneration. Overall, the research on KRT6C recombinant protein not only enhances our understanding of keratin biology but also opens new avenues for clinical applications in dermatology and oncology.
