Analytical Data
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Gene name
GRHL3
- Application
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Alternative Names
Drosophila; Grainyhead like 3; Grainyhead like protein 3 homolog; Grainyhead-like protein 3 homolog; grhl3; GRHL3_HUMAN; Sister of mammalian grainyhead; Sister of mammalian grainyhead protein; SOM; TFCP2L4; Transcription factor CP2 like 4; Transcription factor CP2-like 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TE85
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Expression Region
1-626aa
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AA Sequence
MSNELDFRSV RLLKNDPVNL QKFSYTSEDE AWKTYLENPL TAATKAMMRV NGDDDSVAAL SFLYDYYMGP KEKRILSSST GGRNDQGKRY YHGMEYETDL TPLESPTHLM KFLTENVSGT PEYPDLLKKN NLMSLEGALP TPGKAAPLPA GPSKLEAGSV DSYLLPTTDM YDNGSLNSLF ESIHGVPPTQ RWQPDSTFKD DPQESMLFPD ILKTSPEPPC PEDYPSLKSD FEYTLGSPKA IHIKSGESPM AYLNKGQFYP VTLRTPAGGK GLALSSNKVK SVVMVVFDNE KVPVEQLRFW KHWHSRQPTA KQRVIDVADC KENFNTVEHI EEVAYNALSF VWNVNEEAKV FIGVNCLSTD FSSQKGVKGV PLNLQIDTYD CGLGTERLVH RAVCQIKIFC DKGAERKMRD DERKQFRRKV KCPDSSNSGV KGCLLSGFRG NETTYLRPET DLETPPVLFI PNVHFSSLQR SGGAAPSAGP SSSNRLPLKR TCSPFTEEFE PLPSKQAKEG DLQRVLLYVR RETEEVFDAL MLKTPDLKGL RNAISEKYGF PEENIYKVYK KCKRGETSLL HPRLSRHPPP DCLECSHPVT QVRNMGFGDG FWRQRDLDSN PSPTTVNSLH FTVNSE
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Molecular Weight
70.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GRHL3 (Grainyhead-like 3) is a transcription factor that plays a crucial role in various biological processes, including epithelial development, tissue morphogenesis, and regulation of gene expression. Its involvement in maintaining epithelial integrity has been linked to skin, oral, and gastrointestinal tract health. Research into GRHL3 has revealed its essential function in cellular differentiation and migration, particularly in the context of wound healing and cancer progression. Its expression patterns have been associated with different types of malignancies, suggesting that GRHL3 could serve as a potential biomarker for cancer prognosis and treatment response. The study of GRHL3 recombinant protein is significant for understanding its structural and functional properties, which can aid in elucidating its role in disease mechanisms. Given its critical involvement in epithelial cells, GRHL3 is of interest in therapeutic strategies aimed at promoting wound healing or inhibiting tumor growth. Additionally, investigations into GRHL3's interactions with other proteins and its regulatory networks could uncover novel targets for intervention in diseases where its function is compromised. Overall, the research on GRHL3 recombinant protein not only enhances our understanding of its biological significance but also paves the way for potential clinical applications in regenerative medicine and cancer therapy.
