Analytical Data
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基因名
GRAP
- Application
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别名
Grap; GRAP_HUMAN; GRB2 related adaptor protein; GRB2-related adapter protein; Growth factor receptor bound protein 2 related adaptor protein; MGC64880; OTTHUMP00000065766
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13588
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表达区间
1-217aa
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氨基酸序列
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKKRQIFLRD EEPLLKSPGA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER PDPHWWRGRS CGRVGFFPRS YVQPVHL
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分子量
25.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRAP (GTPase Regulator Associated with Propulsion) is a protein that plays a crucial role in the regulation of GTPases, which are vital for various cellular processes, including signal transduction, cytoskeletal dynamics, and intracellular transport. Research into GRAP has gained prominence due to its potential implications in cancer biology and cellular motility. Understanding the structural and functional characteristics of GRAP can provide insights into its mechanistic pathways and interactions with other proteins. Studies have shown that GRAP is involved in the modulation of GTPase activity, which influences cell proliferation and migration. Given that dysregulation of GTPase signaling is linked to tumorigenesis, GRAP is viewed as a promising target for therapeutic interventions. Moreover, elucidating the effects of GRAP on cell behavior can enhance our knowledge of pathological conditions where cell movement is aberrant, such as in metastasis. The ongoing research focuses on the molecular mechanisms by which GRAP regulates GTPases and its potential as a biomarker or therapeutic target in cancer treatment, thereby underscoring the importance of this protein in both fundamental biology and clinical applications.
