Analytical Data
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基因名
MACROD1
- Application
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别名
MACROD1；LRP16；ADP-ribose glycohydrolase MACROD1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQ69
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表达区间
1-325aa
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氨基酸序列
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGPLLTDECRTLQSCKTGKAKITGGYRLPAKYVIHTVGPIAYGEPSASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPCEAAAEIVLATLREWLEQHKDKVDRLIICVFLEKDEDIYRSRLPHYFPVA
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分子量
39.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MACROD1, also known as "macrodomain-containing protein 1," has garnered significant attention in recent years due to its association with various cellular processes and diseases. This protein is characterized by its unique macrodomain, which is capable of binding to ADP-ribose, a modification that plays a crucial role in cellular signaling, DNA repair, and apoptosis. Research has revealed that MACROD1 is implicated in multiple pathophysiological contexts, including cancer, neurodegenerative disorders, and viral infections. Its potential role in modulating the DNA damage response and cellular stress pathways makes it a promising target for therapeutic interventions. Notably, MACROD1 is involved in the regulation of poly(ADP-ribose) polymerase (PARP) activity, which is vital for maintaining genomic stability. The study of recombinant MACROD1 proteins provides valuable insights into the structural and functional mechanisms underlying its interactions with ADP-ribose and other cellular components. Understanding the biophysical properties of MACROD1 through recombinant expression systems can pave the way for the development of small-molecule inhibitors or modulators that can alter its function, offering potential strategies for disease treatment. Thus, the research on MACROD1 not only enhances our understanding of fundamental cellular processes but also holds promise for the advancement of targeted therapies in various diseases.
