Analytical Data
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Gene name
KATNA1
- Application
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Alternative Names
KATNA1；Katanin p60 ATPase-containing subunit A1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75449
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Expression Region
111-491aa
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AA Sequence
GPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC
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Molecular Weight
50.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KATNA1, or "Katanin-1," is a protein associated with the regulation of microtubule dynamics and has garnered considerable interest in the field of cellular biology and neuroscience. Its role in cytoskeletal organization is crucial for various cellular processes, including cell division, migration, and differentiation. Studies have demonstrated that KATNA1 is involved in the severing of microtubules, which is essential for the proper functioning of neuronal cells, particularly during the development of the nervous system. Dysregulation of KATNA1 has been linked to neurodevelopmental disorders and other pathologies, making it a potential target for therapeutic interventions. Research on KATNA1 often involves the recombination and expression of its protein in vitro to study its functional properties, interactions with other cytoskeletal proteins, and its impact on cellular morphology. By employing techniques such as CRISPR-Cas9 genome editing, yeast two-hybrid screens, and advanced imaging methods, scientists aim to elucidate the precise mechanisms through which KATNA1 influences microtubule organization and neuronal function. Understanding its molecular pathways may provide insights into the development of innovative strategies to address diseases characterized by cytoskeletal dysfunction. As the scientific community continues to explore the multifaceted roles of KATNA1, the potential for new discoveries in cell biology and therapeutic applications remains significant.
