Analytical Data
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基因名
FBXO4
- Application
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别名
FBXO4；FBX4；F-box only Protein 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKT5
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表达区间
1-387aa
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氨基酸序列
MAGSEPRSGTNSPPPPFSDWGRLEAAILSGWKTFWQSVSKERVARTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTDGAFFDYMAVYRMCCPYTRRASKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVNFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSRHNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSHIMAMTDPAFGSSGRPLLVLSCISQGDVKRMPCFYLAHELHLNLLNHPWLVQDTEAETLTGFLNGIEWILEEVESKRAR
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分子量
48.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO4, a member of the F-box protein family, plays a critical role in regulating protein degradation via the ubiquitin-proteasome system. It functions as a substrate-recognition component of E3 ubiquitin ligases, facilitating the ubiquitination of specific target proteins, which are subsequently marked for degradation. The dysregulation of FBXO4 has been implicated in various pathological conditions, including cancer, where it may influence cell cycle regulation and oncogenic signaling pathways. Recent studies suggest that FBXO4 may also participate in cellular processes such as apoptosis and response to oxidative stress. The production of recombinant FBXO4 protein allows researchers to investigate its structure-function relationship, elucidating its role in ubiquitination and potential therapeutic targets. Understanding FBXO4's interactions and mechanisms is vital for developing new strategies for cancer treatment and other diseases associated with protein misregulation. Thus, the recombinant expression and characterization of FBXO4 is not only important for basic research but also for potential clinical applications in designing therapeutics that could manipulate its activity or expression.
