Analytical Data
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基因名
ZIC4
- Application
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别名
ZIC4；Zinc finger Protein ZIC 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N9L1
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表达区间
1-334aa
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氨基酸序列
MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASSAAVAARTADLSE
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分子量
39.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZIC4, a member of the ZIC (Zinc Finger of the Cerebellum) family of transcription factors, plays a critical role in early development, particularly in the formation of the central nervous system. Research into ZIC4 has gained significant attention due to its implications in various neurodevelopmental disorders and its potential as a biomarker for certain neurological conditions. Mutations in the ZIC4 gene have been linked to complex congenital conditions, including agenesis of the corpus callosum and other brain malformations. The protein's structure features multiple zinc-finger motifs, which facilitate its interaction with DNA and other proteins, suggesting that it acts as a transcriptional regulator during embryonic development. Studies aiming to understand the functional mechanisms of ZIC4 have utilized recombinant protein technologies to produce and characterize ZIC4 in vitro. These investigations are essential for elucidating ZIC4's regulatory pathways and identifying potential targets for therapeutic intervention. Understanding ZIC4's role not only advances the field of developmental biology but also opens avenues for research into treatments for related neurodevelopmental disorders.
