Analytical Data
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Gene name
GPR82
- Application
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Alternative Names
GPR82; Probable G-protein coupled receptor 82
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96P67
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Expression Region
1-336aa
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AA Sequence
MNNNTTCIQPSMISSMALPIIYILLCIVGVFGNTLSQWIFLTKIGKKTSTHIYLSHLVTANLLVCSAMPFMSIYFLKGFQWEYQSAQCRVVNFLGTLSMHASMFVSLLILSWIAISRYATLMQKDSSQETTSCYEKIFYGHLLKKFRQPNFARKLCIYIWGVVLGIIIPVTVYYSVIEATEGEESLCYNRQMELGAMISQIAGLIGTTFIGFSFLVVLTSYYSFVSHLRKIRTCTSIMEKDLTYSSVKRHLLVIQILLIVCFLPYSIFKPIFYVLHQRDNCQQLNYLIETKNILTCLASARSSTDPIIFLLLDKTFKKTLYNLFTKSNSAHMQSYG
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Molecular Weight
38.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR82, a member of the G protein-coupled receptor (GPCR) family, has garnered significant interest due to its unique role in various physiological processes and potential implications in disease pathophysiology. Originally identified as an orphan receptor, subsequent research has revealed its involvement in modulating immune responses, metabolism, and neuronal signaling. The expression of GPR82 in various tissues, particularly in the brain and immune cells, suggests that it might play a crucial role in mediating communication between the nervous system and the immune system. Furthermore, dysregulation of GPR82 has been implicated in several conditions, including obesity, inflammation, and neurodegenerative diseases. The generation of recombinant GPR82 proteins is vital for characterizing its ligand interactions and signaling pathways, thereby providing insights into its functional mechanisms. Researchers aim to develop GPR82 antagonists or agonists to explore its therapeutic potential, making the study of its recombinant protein crucial for advancing our understanding of GPR82's biological roles. Overall, the investigation of GPR82 recombinant proteins holds promise not only for basic biological research but also for the development of novel therapeutic strategies targeting metabolic and neuroimmune disorders.
