Analytical Data
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基因名
GPR158
- Application
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别名
5330427M13Rik; GP158_HUMAN; GPR158; mKIAA1136; Probable G-protein coupled receptor 158; RP11-59G22.1; RP23-133B16.1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T848
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表达区间
23-131aa
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氨基酸序列
RDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATN
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分子量
37.73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR158, a member of the G protein-coupled receptor (GPCR) family, has garnered attention in recent years due to its association with various neuropsychiatric disorders and its role in modulating neurotransmission. Despite its potential significance, the functional mechanisms and signaling pathways of GPR158 remain poorly understood, primarily due to the lack of comprehensive studies and structural data. Recent research indicates that GPR158 may play a critical role in the regulation of neuronal excitability and synaptic plasticity, suggesting its involvement in cognitive functions and mood regulation. The investigation of GPR158 recombinant proteins is essential for elucidating its pharmacological properties and interactions with ligands, which could ultimately lead to the development of novel therapeutic strategies targeting neuropsychiatric conditions. Moreover, producing GPR158 as a recombinant protein allows scientists to study its structure-function relationship in detail, facilitating high-throughput screening of small molecules and the identification of potential drug candidates. Understanding GPR158's role in brain function could contribute to the advancement of treatment options for disorders such as depression, anxiety, and schizophrenia, marking a significant step forward in the field of neuropharmacology. Therefore, the research surrounding GPR158 recombinant protein is pivotal not only for basic science but also for its translational implications in developing new therapies aimed at improving mental health outcomes.












