Analytical Data
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Gene name
JPH1
- Application
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Alternative Names
JPH1；JP1；Junctophilin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HDC5
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Expression Region
1-661aa
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AA Sequence
MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADSPAGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQRFQEGVDAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSHSPASSPKPLKKQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPNPSNGELHSQYHGYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKWSPSKSVTKPVAKESKAEPKAKKSELAIPKNPASNDSCPALEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT
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Molecular Weight
71.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
JPH1, also known as Junctophilin-1, is a member of the junctophilin family, which plays a crucial role in the communication between cell membranes and intracellular organelles, specifically in excitable tissues such as muscle and neurons. Research on JPH1 has gained momentum due to its significant involvement in the formation of junctional membrane complexes, which are essential for processes like excitation-contraction coupling in cardiac and skeletal muscle, as well as synaptic transmission in neurons. Dysregulation of JPH1 has been linked to various pathophysiological conditions, including heart disease and neurodegenerative disorders, making it a potential therapeutic target. The recombinant protein production of JPH1 has become a focal point for studies aimed at elucidating its structure-function relationships, interaction with other cellular proteins, and role in myopathies and other diseases. By investigating the recombinant JPH1 protein, researchers aim to better understand the molecular mechanisms underlying its function and pathology, which could lead to novel strategies for drug development and treatment of related diseases. Additionally, the production of JPH1 in a recombinant system allows for the exploration of its biochemical properties, post-translational modifications, and the development of specific antibodies for further exploratory and clinical applications. The ongoing studies on JPH1 promise to shed light on its critical roles in cellular architecture and signaling, providing insights that could extend to broader biological and medical relevance.
