Analytical Data
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基因名
NPR3
- Application
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别名
NPR3；ANPRC；C5orf23；NPRC；Atrial natriuretic peptide receptor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17342
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表达区间
27-481aa
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氨基酸序列
GGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEE
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分子量
53.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPR3 (Natriuretic Peptide Receptor 3) is a member of the natriuretic peptide receptor family, which plays a critical role in cardiovascular and renal physiology. As a receptor for the atrial, brain, and C-type natriuretic peptides, NPR3 is involved in various physiological processes, including regulation of blood pressure, fluid balance, and the modulation of cardiac and vascular function. Research has shown that NPR3 can act as a clearance receptor, thereby regulating the bioavailability of natriuretic peptides and influencing their physiological effects. Dysfunction or altered expression of NPR3 has been implicated in a range of cardiovascular diseases, making it a potential target for therapeutic intervention. Additionally, recent studies have focused on the structural and functional characterization of NPR3, aiming to understand its signaling pathways and interactions with other proteins. Such insights could pave the way for novel treatments aimed at cardiovascular disorders linked to dysregulated natriuretic peptide signaling. Investigating NPR3's role in various pathophysiological conditions is crucial for developing strategies to mitigate its adverse effects and enhance cardiovascular health.
