Analytical Data
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Gene name
TMEM173
- Application
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Alternative Names
TMEM173；ERIS；MITA；STING；Stimulator of interferon genes Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86WV6
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Expression Region
1-379aa
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AA Sequence
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
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Molecular Weight
42.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMEM173, also known as STING (Stimulator of Interferon Genes), is a critical component of the immune response, particularly in the detection of cytosolic DNA and the subsequent activation of the type I interferon pathway. This protein plays a pivotal role in innate immunity, functioning as a sensor for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). The study of recombinant TMEM173 has garnered significant attention in both basic and applied research due to its potential implications in cancer immunotherapy and viral infections. The ability of TMEM173 to activate STING-related signaling cascades can enhance anti-tumor immunity, making it a desirable target for therapeutic interventions. Furthermore, understanding the structure and function of recombinant TMEM173 can provide insights into its role in autoimmune diseases and other pathological conditions linked to dysregulated immune responses. As such, research into TMEM173 not only aims to elucidate fundamental aspects of immune regulation but also to harness its therapeutic potential, particularly in developing STING agonists for clinical applications aimed at boosting the immune system. This has led to ongoing investigations into the protein's signaling mechanisms, interactions with other immune components, and its function in various cellular contexts, positioning TMEM173 as a central figure in the evolving landscape of immunology and therapeutic innovation.
