Analytical Data
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基因名
ELOB
- Application
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别名
ELOB；TCEB2;Elongin-B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15370
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表达区间
2-118aa
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氨基酸序列
DVFLMIRRHK TTIFTDAKES STVFELKRIV EGILKRPPDE QRLYKDDQLL DDGKTLGECG FTSQTARPQA PATVGLAFRA DDTFEALCIE PFSSPPELPD VMKPQDSGSS ANEQAVQ
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELOB, or Elongin B, is part of a regulatory complex involved in the elongation phase of transcription, playing a crucial role in gene expression modulation. Its study is rooted in the understanding of transcriptional regulation mechanisms, which are vital for numerous biological processes, including cell differentiation, development, and responses to environmental stimuli. The ELOB protein acts in conjunction with Elongin C and other components to facilitate the function of RNA polymerase II, ensuring proper transcription elongation. Disruptions in ELOB function have been linked to various diseases, including certain cancers, highlighting its importance in maintaining cellular homeostasis. Consequently, researchers have focused on elucidating the structural and functional properties of ELOB, aiming to understand its interactions within the elongation complex and its broader implications in transcription regulation. Investigating ELOB not only provides insights into the fundamental aspects of gene expression but also opens up potential avenues for therapeutic interventions in diseases associated with transcriptional dysregulation.
