Analytical Data
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Gene name
ECI1
- Application
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Alternative Names
ECI1；DCI;Enoyl-CoA delta isomerase 1. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P42126
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Expression Region
42-302aa
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AA Sequence
FGSQRVLVE PDAGAGVAVM KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RYCIGLNETQ LGIIAPFWLK DTLENTIGHR AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI AQWMAIPDHA RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE KG
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ECI1 (Elongator Complex Component 1) is a crucial protein that plays an integral role in the elongator complex involved in the post-transcriptional modification of transfer RNA (tRNA) and the regulation of gene expression. Its involvement in various cellular processes, including the elongation phase of transcription and the modification of RNA molecules, has prompted significant interest in its study. Research has indicated that ECI1 may have implications in several biological processes, including cell cycle regulation, DNA repair, and response to cellular stress. Understanding the functional mechanisms of ECI1 is particularly important in the context of various diseases, such as cancer, where alterations in RNA processing and gene expression patterns are prevalent. Furthermore, ECI1 has been found to be involved in the modulation of the cell’s response to external stimuli, highlighting its potential role in developmental biology and cellular differentiation. Advances in analytical techniques, such as CRISPR-Cas9 gene editing and high-throughput sequencing, have enabled researchers to explore the intricate functions of ECI1 in greater detail. Identifying the specific pathways and interactions influenced by ECI1 could provide valuable insights into its contribution to cellular homeostasis and the molecular underpinnings of disease states. Given its multifaceted role, the study of ECI1 and its associated pathways continues to be a vibrant area of research, with potential for therapeutic advancements in targeting RNA-related disorders and enhancing our understanding of cellular mechanisms.
