Analytical Data
-
Gene name
fre
- Application
-
Alternative Names
fre；FKHL6；FREAC2；Forkhead box Protein F2
-
Species
E.coli
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P0AEN1
-
Expression Region
2-233aa
-
AA Sequence
TTLSCKVTSVEAITDTVYRVRIVPDAAFSFRAGQYLMVVMDERDKRPFSMASTPDEKGFIELHIGASEINLYAKAVMDRILKDHQIVVDIPHGEAWLRDDEERPMILIAGGTGFSYARSILLTALARNPNRDITIYWGGREEQHLYDLCELEALSLKHPGLQVVPVVEQPEAGWRGRTGTVLTAVLQDHGTLAEHDIYIAGRFEMAKIARDLFCSERNAREDRLFGDAFAFI
-
Molecular Weight
30.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FRE (Ferroportin Regulator) protein research has gained significant attention due to its critical role in iron homeostasis and cellular metabolism. Ferroportin is the only known iron exporter in mammals, responsible for transporting iron from inside cells to the bloodstream. Its regulation is crucial for maintaining proper iron levels, as dysregulation can lead to various health issues such as anemia, hemochromatosis, and other iron overload disorders. Recent studies have identified various factors that influence ferroportin's expression and activity, including hormones like hepcidin, iron levels, and inflammatory cytokines. The understanding of FRE and its mechanism of action is particularly important in the context of diseases linked to iron metabolism, including liver disease, cardiovascular conditions, and neurodegenerative disorders. Furthermore, research on FRE proteins may open new avenues for therapeutic interventions aimed at correcting iron imbalances and improving patient outcomes. As scientists continue to explore the complexities of iron regulation in the body, FRE proteins remain a focal point of investigation, driving advancements in both basic and clinical research. Understanding their function and regulatory mechanisms is essential for developing targeted strategies to manage disorders related to iron metabolism.
