Analytical Data
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Gene name
DUSP18
- Application
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Alternative Names
DUSP18；LMWDSP20;Dual specificity Protein phosphatase 18
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NEJ0
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Expression Region
1-188aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMTAPSCAFPV QFRQPSVSGL SQITKSLYIS NGVAANNKLM LSSNQITMVI NVSVEVVNTL YEDIQYMQVP VADSPNSRLC DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM KYHAMSLLDA HTWTKSCRPI IRPNSGFWEQ LIHYEFQLFG KNTVHMVSSP VGMIPDIYEK EVRLMIPL
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DUSP18, a member of the dual-specificity phosphatase (DUSP) family, plays a crucial role in the regulation of MAPK (mitogen-activated protein kinase) signaling pathways, which are vital for various cellular processes, including proliferation, differentiation, and stress responses. Research on DUSP18 has gained momentum due to its potential implications in cancer biology and other diseases where aberrant MAPK signaling is involved. Unlike many DUSPs that primarily dephosphorylate either tyrosine or serine/threonine residues, DUSP18 can target both, thereby influencing diverse signaling cascades. This unique activity positions DUSP18 as an attractive target for therapeutic intervention. Recent studies have demonstrated that DUSP18 expression is often altered in various cancer types, suggesting a role in tumorigenesis. Additionally, understanding the molecular mechanisms underlying DUSP18 function and its interactions with specific MAPK substrates could provide insights into new pathways for cancer treatment. Thus, recombinant DUSP18 protein is being explored for functional characterization, enabling detailed studies on its enzymatic activity, substrate specificity, and potential as a biomarker or therapeutic target in cancer and other diseases. The ongoing research aims to elucidate the precise roles of DUSP18 in cellular signaling and its contributions to disease states, highlighting its significance in the broader context of MAPK regulation.
