Analytical Data
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Gene name
PTP3
- Application
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Alternative Names
PTP3；PTP2C；SHPTP2；Tyrosine-Protein phosphatase non-receptor type 11
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54637
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Expression Region
1-990aa
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AA Sequence
MISSSMSYRHSTNSVYTLNPHLNIPISTSTTIPPTSFYANNTPEMIQSQSENTNTNNINNSSSNINNNNNNTPDSMSMSTSLSSSPSVSFNHLDLNSINNKINNNTTTNNNNNNNNNNDDKFDTNALKLSNTMIIKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNIEINVPSIQFDNEPAMEVDSVAPLNVPSNHTRTTLAMHNTKSLSTSNIGLLNILPNQQSSSSSSLSSTTTTTTTTSSSLLMPQSLFNNSTYNNHHNNNNSSNAGIVGGLNGSTSSLPTQAQVQLQQMQQQMQQHQQHQYKKANLSSLSTVVDNNLNNNPMNTSTSSPAQPNASPFSFSSSSLFSNSSLSNSGSGSASTTSTSTSSSNSMSSSPPPSLKTSFSQLDEDREKMRLEFEMIKKPEMASKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGIRSLSSPSKRRSCEMIKSTPMPRLDISIPPPLTFTPKDFQSSISPSTDMIASLSIITQMTQTLKFPPQQQQDNPFSKSSIKISPSPLNSTNISIPKNQQFQHPFQIQPQLDLNLQQQQQQSSQQLNDNPPLNMSSNSIKFPPVTSLSSCHLFEDSKNNDNNNKQQQQQQQQQQKNNQQCSGFSHFLNNNNNNDNNGSSGGGFNGSFLFNSNNSGSSSTNSECSNNNKNNNNNSNNNNNNNNNKNSDNNGTKDKDENDSCESPRVTPIKCF
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Molecular Weight
110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTP3 (Protein Tyrosine Phosphatase 3) is a member of the protein tyrosine phosphatase family, which plays a crucial role in cellular signaling processes by dephosphorylating tyrosine residues on proteins. This regulatory mechanism is essential for various biological functions, including cell growth, differentiation, and the immune response. The study of PTP3 is particularly significant due to its involvement in pathological conditions, including cancer and neurodegenerative diseases, where dysregulation of tyrosine phosphorylation can lead to aberrant cell signaling. Research has shown that PTP3 may interact with key signaling pathways, potentially influencing tumor progression and resistance to therapies. Moreover, understanding the structure and function of PTP3 can provide insights into its role in disease mechanisms and facilitate the development of targeted therapeutics. Recent advancements in biochemical techniques and structural biology have enabled researchers to investigate the catalytic mechanisms, substrate specificity, and regulatory interactions of PTP3, paving the way for developing novel inhibitors or modulators that could benefit therapeutic strategies. This growing interest underscores the importance of PTP3 as a potential biomarker and therapeutic target in various diseases, highlighting the necessity for further research into its functional implications in health and disease.
