Analytical Data
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Gene name
DNAJC24
- Application
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Alternative Names
DNAJC24；DPH4；ZCSL3;DnaJ homolog subfamily C member 24
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P3W2
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Expression Region
1-148aa
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AA Sequence
MAVEQMPKKD WYSILGADPS ANISDLKQKY QKLILMYHPD KQSTDVPAGT VEECVQKFIE IDQAWKILGN EETKREYDLQ RCEDDLRNVG PVDAQVYLEE MSWNEGDHSF YLSCRCGGKY SVSKDEAEEV SLISCDTCSL IIELLHYN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJC24, a member of the DnaJ heat shock protein family, plays a crucial role in protein folding and cellular stress responses. It is involved in the chaperone-assisted folding of nascent polypeptides, ensuring proteins achieve their functional conformations and preventing aggregation under stress conditions. Research has demonstrated that DNAJC24 is localized to the mitochondria, suggesting its involvement in mitochondrial protein homeostasis, which is vital for cellular energy metabolism and apoptosis regulation. Mutations in DNAJC24 have been linked to various mitochondrial diseases, highlighting its significance in maintaining mitochondrial function and overall cellular health. Furthermore, DNAJC24 has been shown to interact with several mitochondrial proteins, potentially influencing pathways related to neurodegeneration and age-related disorders. Given its pivotal role in cellular fitness, the study of recombinant DNAJC24 is critical for understanding its biochemical properties and functional mechanisms. This knowledge can provide insights into the molecular basis of mitochondrial dysfunction and may pave the way for developing therapeutic strategies for diseases linked to protein misfolding and mitochondrial impairments. Overall, investigating recombinant DNAJC24 not only enhances our comprehension of mitochondrial biology but also contributes to the broader field of molecular chaperones in health and disease.
