Analytical Data
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基因名
DNAJC24
- Application
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别名
DNAJC24；DPH4；ZCSL3;DnaJ homolog subfamily C member 24
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P3W2
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表达区间
1-148aa
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氨基酸序列
MAVEQMPKKD WYSILGADPS ANISDLKQKY QKLILMYHPD KQSTDVPAGT VEECVQKFIE IDQAWKILGN EETKREYDLQ RCEDDLRNVG PVDAQVYLEE MSWNEGDHSF YLSCRCGGKY SVSKDEAEEV SLISCDTCSL IIELLHYN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNAJC24, a member of the DnaJ heat shock protein family, plays a crucial role in protein folding and cellular stress responses. It is involved in the chaperone-assisted folding of nascent polypeptides, ensuring proteins achieve their functional conformations and preventing aggregation under stress conditions. Research has demonstrated that DNAJC24 is localized to the mitochondria, suggesting its involvement in mitochondrial protein homeostasis, which is vital for cellular energy metabolism and apoptosis regulation. Mutations in DNAJC24 have been linked to various mitochondrial diseases, highlighting its significance in maintaining mitochondrial function and overall cellular health. Furthermore, DNAJC24 has been shown to interact with several mitochondrial proteins, potentially influencing pathways related to neurodegeneration and age-related disorders. Given its pivotal role in cellular fitness, the study of recombinant DNAJC24 is critical for understanding its biochemical properties and functional mechanisms. This knowledge can provide insights into the molecular basis of mitochondrial dysfunction and may pave the way for developing therapeutic strategies for diseases linked to protein misfolding and mitochondrial impairments. Overall, investigating recombinant DNAJC24 not only enhances our comprehension of mitochondrial biology but also contributes to the broader field of molecular chaperones in health and disease.
