Analytical Data
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Gene name
DNAJC19
- Application
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Alternative Names
DNAJC19；TIM14；TIMM14;Mitochondrial import inner membrane translocase subunit TIM14
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96DA6
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Expression Region
19-116aa
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AA Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGRY VLQAMKHMEP QVKQVFQSLP KSAFSGGYYR GGFEPKMTKR EAALILGVSP TANKGKIRDA HRRIMLLNHP DKGGSPYIAA KINEAKDLLE GQAKK
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJC19 is a member of the DnaJ/Hsp40 protein family, which plays a crucial role in protein folding and maintaining cellular protein homeostasis. It is particularly important in the context of mitochondrial function, where it assists in the import and folding of proteins that are essential for mitochondrial biogenesis and function. Mutations in the DNAJC19 gene have been linked to a group of inherited mitochondrial disorders characterized by cardiomyopathy and other neuromuscular symptoms. Due to its significant role in mitochondrial health, DNAJC19 has emerged as a target for understanding the molecular mechanisms underlying these diseases. Research on recombinant DNAJC19 protein has gained momentum as scientists seek to elucidate its functional properties, interaction partners, and the impact of disease-related mutations on its activity. Producing recombinant forms of DNAJC19 allows for detailed biochemical analyses, enabling researchers to study its folding, chaperone activity, and interaction with mitochondrial proteins, thereby providing insights into its role in disease pathology. Additionally, understanding the functional implications of DNAJC19 may pave the way for potential therapeutic approaches in treating mitochondrial disorders associated with its dysregulation. Overall, the investigation of recombinant DNAJC19 protein holds promise for advancing our knowledge of mitochondrial biology and developing effective strategies for related genetic diseases.
