Analytical Data
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Gene name
DNAJB6
- Application
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Alternative Names
DNAJB6；HSJ2；MRJ；MSJ1;DnaJ homolog subfamily B member 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75190
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Expression Region
1-326aa
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AA Sequence
ab105132 is purified using conventional chromatography techniques.
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Molecular Weight
39 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJB6 is a member of the Hsp40 (heat shock protein 40) family, known for its crucial role in protein folding, chaperoning, and stress response mechanisms within cells. Research on DNAJB6 has gained prominence due to its involvement in various neurodegenerative diseases, particularly in the context of protein misfolding and aggregation. Mutations in the DNAJB6 gene have been linked to late-onset myopathy and other muscular disorders, highlighting its importance in maintaining proteostasis. The recombinant expression of DNAJB6 provides a valuable tool for studying its functional mechanisms, interactions with other chaperones, and its role in mitigating the effects of toxic protein aggregates. Furthermore, understanding the biochemical properties and cellular functions of DNAJB6 can offer insights into therapeutic strategies for diseases stemming from protein misfolding, such as Alzheimer's and Huntington's disease. As researchers continue to explore its potential, the generation and characterization of recombinant DNAJB6 protein are expected to advance our understanding of its role in cellular stress responses and open avenues for developing targeted interventions in related pathologies.
