Analytical Data
-
Gene name
SGLT1
- Application
-
Alternative Names
SGLT1；NAGT；SGLT1；Sodium/glucose cotransporter 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P13866
-
Expression Region
1-664aa
-
AA Sequence
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
-
Molecular Weight
73.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of SGLT1 (Sodium-Glucose Cotransporter 1) recombinant protein has garnered significant interest due to its vital role in glucose absorption in the intestines and reabsorption in the kidneys. SGLT1 is a membrane protein that facilitates the transport of glucose into cells against its concentration gradient by coupling it with sodium ion transport. This mechanism is crucial for maintaining glucose homeostasis and energy balance in the body. Dysregulation of SGLT1 function has been linked to various metabolic disorders, including diabetes and malabsorption syndromes. Research on recombinant SGLT1 protein provides valuable insights into its structural and functional properties, enabling the development of targeted therapeutic strategies that could enhance glucose uptake in patients with glucose transport deficiencies. Furthermore, studying SGLT1 can also inform drug design, particularly in the context of SGLT inhibitors, which are used as anti-diabetic medications to reduce glucose reabsorption and lower blood sugar levels. Advances in recombinant DNA technology have facilitated the production of SGLT1 in heterologous systems, allowing for detailed biochemical and pharmacological studies. This research is crucial not only for understanding SGLT1’s physiological roles but also for developing novel treatments for conditions associated with its dysfunction.
