Analytical Data
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Gene name
DHX36
- Application
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Alternative Names
(DEAD/H box polypeptide 36)(DEAH-box protein 36)(G4-resolvase-1)(G4R1)(MLE-like protein 1)(RNA helicase associated with AU-rich element protein)
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2U1
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Expression Region
89-179aa
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Molecular Weight
18.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DHX36, a member of the DExH-box protein family, is an RNA helicase involved in various cellular processes, including RNA metabolism and gene regulation. Its role in unwinding RNA duplexes and facilitating ribonucleoprotein particle assembly is crucial for maintaining cellular homeostasis. Emerging studies have highlighted DHX36's involvement in the regulation of transcription, splicing, and the response to viral infections, suggesting that it can influence the expression of genes crucial for cellular stress responses. Moreover, DHX36 has been implicated in the modulation of innate immune responses, particularly in the context of double-stranded RNA sensing and the activation of interferon pathways. Its dysfunction is associated with several diseases, including cancer and neurodegenerative disorders, leading to an increasing interest in understanding its molecular mechanisms and therapeutic potential. Recombining DHX36 enables researchers to elucidate its structure-function relationships, study its interactions with various RNA substrates, and explore its role in cellular signaling pathways. Understanding the dynamics of DHX36 interaction with RNA could reveal insights into RNA processing and the implications of its misregulation in disease states. This makes DHX36 a promising target for future research aimed at developing RNA-targeted therapies and enhancing our comprehension of the complexities of RNA biology. As a result, the recombinant expression and functional characterization of DHX36 are essential steps in addressing these significant biological questions and advancing medical applications.
