Analytical Data
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基因名
METTL4
- Application
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别名
(6)(Methyltransferase-like protein 4)(N(6), (snRNA (2'-O-methyladenosine-N(6)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N3J2
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表达区间
1-472aa
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分子量
61.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
METTL4, a member of the methyltransferase-like (METTL) protein family, has garnered attention in recent years due to its potential role in RNA methylation, a critical post-transcriptional modification that influences gene expression and cellular function. This protein is involved in adding methyl groups to specific RNA molecules, which can affect their stability, translation efficiency, and interaction with other cellular factors. Preliminary studies suggest that METTL4 may play a significant role in various biological processes, including development, stress response, and immune regulation. However, the precise mechanisms by which METTL4 exerts its effects, as well as its specific RNA targets, remain largely unexplored. Understanding the functional dynamics of METTL4 and its impact on RNA metabolism is crucial, as dysregulation of RNA methylation has been implicated in several diseases, including cancer and neurological disorders. Research on METTL4 recombinant protein aims to elucidate its biochemical properties, interaction networks, and functional implications in cellular pathways. This knowledge may not only enhance our understanding of RNA methylation but also contribute to the development of novel therapeutic strategies targeting RNA-modifying enzymes in disease contexts.
