Analytical Data
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Gene name
GLUT3
- Application
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Alternative Names
GLUT3；GLUT3；Solute carrier family 2. facilitated glucose transporter member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11169
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Expression Region
1-496aa
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AA Sequence
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKG NAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLL AVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTAL RGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSA ALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMS QEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMT VSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPA AMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKV PETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
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Molecular Weight
80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GLUT3 (Glucose Transporter Type 3) is a critical member of the glucose transporter family, primarily responsible for facilitating glucose uptake in neurons and other tissues with high-energy demands. Due to its significant role in maintaining glucose homeostasis and its involvement in various neurological functions, GLUT3 has attracted considerable attention in research, particularly regarding its implications in neurological disorders and metabolic diseases. The understanding of GLUT3's structure, function, and regulatory mechanisms is essential for developing therapeutic strategies targeting metabolic dysregulation in conditions like diabetes, obesity, and neurodegenerative diseases. Recombinant protein studies of GLUT3 provide valuable insights into its kinetic properties, substrate specificity, and interaction with different ligands. By employing techniques such as heterologous expression in yeast or mammalian cells, researchers are able to produce functional GLUT3 for detailed biochemical and pharmacological characterizations. Furthermore, elucidating the structural aspects of GLUT3 using techniques like X-ray crystallography or cryo-electron microscopy could pave the way for the design of novel drugs that specifically modulate GLUT3 activity, potentially offering new avenues for treating diseases linked to glucose metabolism. Understanding GLUT3 not only enhances our grasp of fundamental cellular processes but also shapes our approach to addressing metabolic and neurological disorders prevalent in contemporary society.
