Analytical Data
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基因名
AHSA1
- Application
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别名
AHSA1；C14orf3；Activator of 90 kDa heat shock Protein ATPase homolog 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95433
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表达区间
2-338aa
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氨基酸序列
AKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA LKTEERKAKP APSKTQARPV GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA TLEADRGGKF HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGHFATITLT FIDKNGETEL CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF
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分子量
38.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AHSA1, or Activator of HSP90 ATPase Activity 1, is a crucial co-chaperone protein that plays a significant role in the heat shock protein 90 (HSP90) chaperone machinery. It facilitates the activation of HSP90, which is essential for the proper folding, maturation, and functioning of numerous client proteins, including key oncogenes and regulatory proteins involved in cancer signaling, cell cycle regulation, and apoptosis. Research into AHSA1 has garnered interest due to its implication in various diseases, particularly cancer, where it has been found to be overexpressed in several tumor types, potentially correlating with poor prognosis. Understanding the molecular mechanisms and pathways involving AHSA1 could provide insights into its role in tumor progression and may reveal novel therapeutic targets. Recent studies using recombinant AHSA1 proteins have aimed to elucidate its structural and functional properties, interactions with HSP90, and influence on client protein stability. This growing body of research underscores the importance of AHSA1 not only as a fundamental component of the cellular stress response but also as a potential biomarker and therapeutic target in cancer treatment strategies. The investigation of AHSA1's roles and mechanisms continues to evolve, with promising results in preclinical studies suggesting the potential for AHSA1-targeted therapies to enhance the efficacy of existing cancer treatments.
