Analytical Data
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基因名
DDIT4
- Application
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别名
DDIT4；REDD1；RTP801;DNA damage-inducible transcript 4 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NX09
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表达区间
1-232aa
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氨基酸序列
MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDIT4 (DNA Damage Inducible Transcript 4), also known as REDD1 (Regulated in Development and DNA Damage Responses 1), plays a crucial role in cellular responses to stress and is implicated in various physiological processes, including metabolism, cell growth, and apoptosis. Its expression is regulated in response to hypoxia, nutrient deprivation, and DNA damage, positioning it as a significant player in the cellular adaptation mechanisms. Research into DDIT4 is particularly relevant in the context of cancer, as its aberrant regulation has been linked to tumor progression and resistance to therapy. Additionally, DDIT4 modulates the mTOR (mechanistic target of rapamycin) signaling pathway, which is essential for cellular growth and proliferation, making it a potential target for therapeutic intervention. Recent studies have focused on elucidating the molecular mechanisms underpinning DDIT4 function and its interactions with other pathways. The recombinant protein form of DDIT4 is of great interest because it allows for detailed structural and functional analyses. Understanding the biophysical properties and biological activities of recombinant DDIT4 can facilitate insights into its role in disease states, paving the way for novel therapeutic approaches. Overall, the study of recombinant DDIT4 protein represents a promising avenue for advancing our understanding of cellular stress responses and their implications in cancer and other pathologies.
