Analytical Data
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基因名
CX3CL1
- Application
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别名
CX3CL1；FKN；NTT；SCYD1;Fractalkine
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78423
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表达区间
25-100aa
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氨基酸序列
QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG
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分子量
42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CX3CL1, also known as fractalkine, is a unique chemokine that plays a crucial role in the immune response and inflammation. It exists in two forms: a membrane-bound form that facilitates adhesion and a soluble form that mediates signaling in the immune system. The significance of CX3CL1 is underscored by its involvement in various physiological and pathological processes, including cell migration, neuroinflammation, and tissue repair. Research indicates that CX3CL1 interacts with its receptor, CX3CR1, which is expressed on various immune cells, leading to chemotaxis and immune modulation. Dysregulation of this signaling pathway is associated with several diseases, including chronic inflammatory conditions, neurodegenerative disorders, and cancer. The development of recombinant CX3CL1 protein has been pivotal for studying its structure-function relationship, unveiling its role in immune cell dynamics, and understanding its therapeutic potential. Scientists produce this recombinant protein to investigate its function in vitro and in vivo, aiming to elucidate its mechanisms in disease contexts and explore its potential as a biomarker or therapeutic target. As research progresses, understanding the multifaceted roles of CX3CL1 may offer new avenues for therapeutic interventions in diseases characterized by immune dysregulation.
