Analytical Data
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基因名
CSTF1
- Application
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别名
CSTF1;Cleavage stimulation factor subunit 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q05048
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表达区间
1-431aa
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氨基酸序列
MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG QLIATGSADA SIKILDTERM LAKSAMPIEV MMNETAQQNM ENHPVIRTLY DHVDEVTCLA FHPTEQILAS GSRDYTLKLF DYSKPSAKRA FKYIQEAEML RSISFHPSGD FILVGTQHPT LRLYDINTFQ CFVSCNPQDQ HTDAICSVNY NSSANMYVTG SKDGCIKLWD GVSNRCITTF EKAHDGAEVC SAIFSKNSKY ILSSGKDSVA KLWEISTGRT LVRYTGAGLS GRQVHRTQAV FNHTEDYVLL PDERTISLCC WDSRTAERRN LLSLGHNNIV RCIVHSPTNP GFMTCSDDFR ARFWYRRSTT DVEHHHHHH
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分子量
49 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSTF1, or Cleavage Stimulating Factor 1, is an essential component of the cleavage and polyadenylation machinery that plays a crucial role in the post-transcriptional regulation of gene expression. It is involved in the processing of pre-mRNA, facilitating the cleavage of nascent transcripts and the subsequent addition of poly(A) tails, which are vital for mRNA stability, export, and translation. Research on CSTF1 has garnered significant interest due to its implications in various biological processes, including cell proliferation, differentiation, and response to stress. Furthermore, abnormalities in CSTF1 expression or function have been linked to several diseases, including cancer and neurodegenerative disorders. Understanding the structure, function, and regulatory mechanisms of CSTF1 is therefore critical for deciphering its role in normal physiology and disease states. Recent studies utilizing recombinant CSTF1 proteins have enabled the exploration of its biochemical properties, interaction with other nuclear factors, and the impact of post-translational modifications. These investigations are paving the way for potential therapeutic interventions targeting CSTF1-related pathways, highlighting the protein's significance in cellular homeostasis and disease etiology.
