Analytical Data
-
Gene name
LPAR1
- Application
-
Alternative Names
LPAR1；EDG2；LPA1；Lysophosphatidic acid receptor 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q92633
-
Expression Region
1-364aa
-
AA Sequence
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSK LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL AYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITV FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAP LYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNR DTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNH TILAGVHSNDHSVV
-
Molecular Weight
68 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LPAR1, or Lysophosphatidic Acid Receptor 1, is a G-protein-coupled receptor that plays a crucial role in various physiological and pathological processes, including cell proliferation, survival, migration, and differentiation. It is activated by lysophosphatidic acid (LPA), a bioactive lipid involved in several cellular signaling pathways. Significant research has linked LPAR1 to conditions such as cancer, fibrosis, and neurodegenerative diseases, highlighting its potential as a therapeutic target. Due to its involvement in disease progression, the characterization and production of LPAR1 recombinant proteins are of great interest. By utilizing techniques such as molecular cloning and expression in suitable host systems, researchers aim to produce functional LPAR1 proteins for structural and functional studies. These studies are vital for understanding the receptor's signaling mechanisms, interaction with ligands, and potential modulation by small molecules. Furthermore, LPAR1's role in promoting tumor growth and metastasis has made it a focus in cancer research, leading to the exploration of LPAR1 antagonists as novel cancer therapies. Overall, the investigation of LPAR1, particularly through the development of recombinant proteins, serves as a foundation for both basic research and the advancement of therapeutic strategies targeting various diseases.
