Analytical Data
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基因名
CHD5
- Application
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别名
CHD5;KIAA0444;Chromodomain-helicase-DNA-binding Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TDI0
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHD5 (Chromodomain Helicase DNA Binding Protein 5) is a member of the CHD family of proteins that play a critical role in chromatin remodeling and gene regulation. Recent studies have highlighted the importance of CHD5 in various biological processes, including cell proliferation, differentiation, and response to DNA damage. Notably, CHD5 has been identified as a potential tumor suppressor, particularly in neuroblastoma, where it is frequently found to be downregulated or deleted in affected patients. The interest in CHD5 has surged as it appears to influence critical pathways involved in cancer development, making it a compelling target for therapeutic research. Researchers are investigating the functional mechanisms of CHD5, including its interaction with DNA and other chromatin-associated proteins, to better understand its role in maintaining genomic stability and preventing oncogenesis. Furthermore, the recombinant expression of CHD5 protein allows for in-depth studies of its biochemical properties and interactions, paving the way for potential applications in cancer therapy. The elucidation of CHD5's mechanisms could ultimately contribute to the development of novel strategies for early detection, targeted treatment, and personalized medicine in tumor management. As the landscape of cancer biology continues to evolve, CHD5 stands out as a promising candidate for further exploration in understanding the complexities of tumorigenesis and improving clinical outcomes for patients.












