Analytical Data
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Gene name
CPEB1
- Application
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Alternative Names
CPEB1；CPEB;Cytoplasmic polyadenylation element-binding Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZB8
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Expression Region
1-486aa
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AA Sequence
MLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAALAAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGYVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKNRDSS
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Molecular Weight
69.6kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPEB1, or Cytoplasmic Polyadenylation Element Binding Protein 1, is a crucial regulatory protein involved in the control of mRNA translation and stability, particularly in neuronal cells. It plays a significant role in the regulation of polyadenylation, influencing the length of poly(A) tails in mRNA, which affects the onset of translation and the fate of the mRNA in the cytoplasm. The study of CPEB1 has garnered significant attention due to its implications in various physiological processes, including synaptic plasticity, learning, and memory formation. Dysregulation of CPEB1 has been linked to several neurological disorders and conditions, such as Alzheimer's disease and other neurodegenerative disorders. Researchers have been actively investigating the biochemical properties of CPEB1, its interactions with other cellular molecules, and its role in mRNA metabolism. Recombinant CPEB1 protein has been generated for structural and functional studies, enabling scientists to delve deeper into its mechanisms and potential as a therapeutic target. Understanding the nuances of CPEB1 function holds promise for developing new strategies for treating cognitive dysfunction and enhancing brain health.
