Analytical Data
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基因名
COA4
- Application
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别名
COA4；CHCHD8；E2IG2;Cytochrome c oxidase assembly factor 4 homolog. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYJ1
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表达区间
1-87aa
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氨基酸序列
MSTSVPQGHT WTQRVKKDDE EEDPLDQLIS RSGCAASHFA VQECMAQHQD WRQCQPQVQA FKDCMSEQQA RRQEELQRRQ EQAGAHH
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COA4 (Coenzyme A Synthetase 4) is a non-canonical enzyme that plays a critical role in the mitochondrial bioenergetics, particularly in the biosynthesis of Coenzyme A (CoA), an essential cofactor involved in various metabolic pathways. Research on COA4 has gained traction due to its potential implications in mitochondrial dysfunction and related diseases, including metabolic disorders and neurodegenerative conditions. As mitochondrial health is closely linked to overall cellular energy metabolism and oxidative stress regulation, understanding the structure and function of COA4 is paramount. Recent studies have focused on the recombinant expression and characterization of COA4 protein to elucidate its biochemical properties and regulatory mechanisms. This research aims to identify the enzymatic activity of COA4, its interaction with other metabolic partners, and its role in cellular energy homeostasis. By generating recombinant COA4, researchers can explore various factors affecting its activity and stability, which may yield novel insights into therapeutic targets for diseases associated with mitochondrial dysfunction. Such investigations not only enhance our fundamental understanding of CoA metabolism but also pave the way for the development of targeted interventions in related health conditions.
