Analytical Data
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Gene name
Bicd2
- Application
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Alternative Names
(Bic-D 2)
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Species
Mouse
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q921C5
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Expression Region
660-813aa
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Molecular Weight
44.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Bicd2 (Bicaudal D Homolog 2) is an important protein implicated in intracellular transport processes, specifically in the transport of cellular components along microtubules. It is known to play a crucial role in the localization of mRNA and proteins within cells, influencing various aspects of cell biology, including cell division, differentiation, and the maintenance of cellular architecture. Research has shown that Bicd2 interacts with dynein, a motor protein that moves cargo towards the minus end of microtubules, thereby facilitating the retrograde transport necessary for processes like endocytosis and lysosome positioning. In the context of neurobiology, Bicd2 has been found to be essential for axonal transport and proper neuronal function, indicating its potential involvement in neurodegenerative diseases when these transport mechanisms are disrupted. Given its significant role in cellular transport and development, understanding the structure and function of recombinant Bicd2 protein is critical for elucidating its mechanisms of action and potential as a therapeutic target. Recent studies on the recombinant expression and purification of Bicd2 aim to explore its functional properties, binding interactions, and its role in various cellular pathways, advancing our knowledge of the molecular underpinnings of cellular transport and its implications in health and disease.
