Analytical Data
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基因名
PAG1
- Application
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别名
PAG1；CBP；PAG；PhosphoProtein associated with glycosphingolipid-enriched microdomains 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWQ8
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表达区间
38-432aa
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氨基酸序列
SSCDREKKPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPASSEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKPKCHQSRELPRIPPESAVDTMLTARSVDGDQGLGMEGPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQTEGKAEFAEYASVDRNKKCRQSVNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAEESATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQLVNKSGQSLTVPESTYTSIQGDPQRSPSSCNDLYATVKDFEKTPNSTLPPAGRPSEEPEPDYEAIQTLNREEEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL
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分子量
50.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAG1 (Phosphoprotein associated with glycosphingolipid-enriched microdomains 1) is a multi-functional protein heavily researched for its role in various cellular processes, particularly in relation to cancer and immune signaling. It is primarily expressed in immune cells, where it is involved in the regulation of cell signaling pathways that control cell growth, differentiation, and death. Studies have indicated that PAG1 can act as a negative regulator of several signaling pathways, including the T-cell receptor signaling pathway, thus playing a crucial role in maintaining cellular homeostasis. In cancer research, PAG1's involvement in tumor progression and metastasis has garnered significant interest, as altered expression levels of PAG1 have been associated with various malignancies, including breast and colon cancer. The development of recombinant PAG1 proteins allows for detailed studies of its structure-function relationships and interactions with other signaling molecules, providing insights into its biological roles. Furthermore, understanding PAG1's molecular mechanisms could lead to potential therapeutic strategies targeting its pathway, aiming to enhance immune responses or inhibit tumor growth. Overall, research on PAG1 is pivotal for unraveling the complexities of cell signaling in health and disease, thereby fostering advancements in both basic biology and clinical applications.
