Analytical Data
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Gene name
SGPP2
- Application
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Alternative Names
SGPP2；Sphingosine-1-phosphate phosphatase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IWX5
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Expression Region
1-399aa
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AA Sequence
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP
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Molecular Weight
44.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SGPP2 (sphingosine-1-phosphate phosphatase 2) is a vital enzyme involved in sphingolipid metabolism, playing a crucial role in regulating sphingosine-1-phosphate (S1P) levels within cells. Elevated S1P levels are implicated in various physiological processes, such as cell proliferation, survival, migration, and immune responses. Dysregulation of S1P signaling has been associated with a range of pathological conditions, including cancer, cardiovascular diseases, and inflammatory disorders. The study of SGPP2 is particularly significant due to its potential as a therapeutic target; it can modulate S1P concentrations, thereby influencing numerous signaling pathways. Research on SGPP2 recombinant proteins enables a deeper understanding of its structure-function relationship, as well as its regulatory mechanisms in sphingolipid metabolism. Furthermore, exploring the biochemical properties and functional roles of the SGPP2 protein can provide insights into its contributions to both normal cellular processes and disease states, making it a promising candidate for drug discovery and the development of novel therapeutics aimed at modulating S1P signaling. Understanding SGPP2's role in cellular homeostasis and its implications in disease pathogenesis is crucial for advancing therapeutic strategies targeting sphingolipid metabolism.
