Analytical Data
-
基因名
SGPP2
- Application
-
别名
SGPP2；Sphingosine-1-phosphate phosphatase 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8IWX5
-
表达区间
1-399aa
-
氨基酸序列
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP
-
分子量
44.7 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SGPP2 (sphingosine-1-phosphate phosphatase 2) is a vital enzyme involved in sphingolipid metabolism, playing a crucial role in regulating sphingosine-1-phosphate (S1P) levels within cells. Elevated S1P levels are implicated in various physiological processes, such as cell proliferation, survival, migration, and immune responses. Dysregulation of S1P signaling has been associated with a range of pathological conditions, including cancer, cardiovascular diseases, and inflammatory disorders. The study of SGPP2 is particularly significant due to its potential as a therapeutic target; it can modulate S1P concentrations, thereby influencing numerous signaling pathways. Research on SGPP2 recombinant proteins enables a deeper understanding of its structure-function relationship, as well as its regulatory mechanisms in sphingolipid metabolism. Furthermore, exploring the biochemical properties and functional roles of the SGPP2 protein can provide insights into its contributions to both normal cellular processes and disease states, making it a promising candidate for drug discovery and the development of novel therapeutics aimed at modulating S1P signaling. Understanding SGPP2's role in cellular homeostasis and its implications in disease pathogenesis is crucial for advancing therapeutic strategies targeting sphingolipid metabolism.
