Cat: PA1000-598DB

Recombinant Human CHAC2 Protein,His

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Analytical Data

  • Gene name

    CHAC2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CHAC2;Glutathione-specific gamma-glutamylcyclotransferase 2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8WUX2

  • Expression Region

    1-184aa

  • AA Sequence

    MGSSHHHHHH SSGLVPRGSH MGSMWVFGYG SLIWKVDFPY QDKLVGYITN YSRRFWQGST DHRGVPGKPG RVVTLVEDPA GCVWGVAYRL PVGKEEEVKA YLDFREKGGY RTTTVIFYPK DPTTKPFSVL LYIGTCDNPD YLGPAPLEDI AEQIFNAAGP SGRNTEYLFE LANSIRNLVP EEADEHLFAL EKLVKERLEG KQNLNCI

  • Molecular Weight

    23 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

Related Products

Protein Description

The CHAC2 protein, a member of the ChaC family of proteins, has garnered attention for its potential role in regulating cellular responses to oxidative stress. Identified in humans and several other organisms, CHAC2 is primarily localized in the mitochondria and has been linked to apoptosis and programmed cellular death pathways. Research indicates that CHAC2 plays a crucial role in cellular homeostasis by mediating the detoxification of harmful reactive oxygen species (ROS). Its expression is upregulated in various stress conditions, suggesting a protective mechanism against oxidative damage. As oxidative stress is implicated in numerous diseases, including neurodegenerative disorders and cancer, studying the reconstitution and functional properties of CHAC2 can provide insights into its biological significance. Understanding the biochemical pathways involving CHAC2 may reveal novel therapeutic targets for diseases characterized by oxidative stress, enhancing our overall grasp of mitochondrial dynamics and cellular health. Consequently, the recombinant production of CHAC2 allows for in-depth characterization of its functional roles and interactions, paving the way for innovative strategies in disease management and treatment development.

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