Analytical Data
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Gene name
U2AF1L4
- Application
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Alternative Names
U2 auxiliary factor 26 U2 small nuclear RNA auxiliary factor 1-like protein 4
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WU68
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Expression Region
1-202aa
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
U2AF1L4, a member of the U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) family, plays a critical role in the regulation of pre-mRNA splicing, a vital process for gene expression in eukaryotic cells. This protein specifically binds to the splicing acceptor sequences and facilitates the recruitment of the spliceosome, thus ensuring accurate splicing of precursor mRNA into mature mRNA. Recent studies have highlighted the significance of U2AF1L4 in developmental biology and oncogenesis, as mutations in U2AF1 and related genes can lead to various hematological malignancies and other cancers. Given its essential function in splicing regulation, researchers are increasingly focused on understanding the structural and functional properties of U2AF1L4, particularly how it interacts with RNA and other splicing factors. The exploration of U2AF1L4’s role in cellular processes and its potential implication in diseases offers promising avenues for therapeutic interventions, including the development of small molecules or RNA-based strategies to modulate its activity. Through detailed investigations into its mechanisms and regulatory networks, scientists aim to unravel the complexities of RNA processing and its effects on cellular homeostasis and disease pathology. This research not only enhances our understanding of fundamental biological processes but also contributes to the broader field of gene therapy and personalized medicine.
